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is a medicine of the benzodiazepine family that acts as an anxiolytic.
It is commonly used to treat a range of conditions, including anxiety,
seizures, alcohol withdrawal syndrome, benzodiazepine
withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome.
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When given into a vein, effects begin in one to five minutes and last up to an hour.
By mouth, effects begin after 15 to 60 minutes.
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Common side effects include sleepiness and trouble with coordination.
Serious side effects are rare. They include suicide, decreased breathing,
Occasionally, excitement or agitation may occur.
Long term use can result in tolerance, dependence,
and withdrawal symptoms on dose reduction.
After stopping, cognitive problems may persist for six months or longer.
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Its mechanism of action is by increasing the effect of the
neurotransmitter gamma-aminobutyric acid (GABA).
In the United States it was the highest selling medication between
1968 and 1982, selling more than 2 billion tablets in 1978 alone.
In 2018, it was the 115th most commonly prescribed
In 1985 the patent ended, and there are more than 500 brands available on the market.
Diazepam is the drug of choice for treating benzodiazepine
dependence with its long half-life allowing easier dose reduction.
Diazepam has a number of uses including:
- Treatment of anxiety, panic attacks, and states of agitation
- Treatment of neurovegetative symptoms associated with vertigo
- Treatment of the symptoms of alcohol, opiate, and benzodiazepine withdrawal
- Short-term treatment of insomnia
- Treatment of muscle spasms
- Treatment of tetanus, together with other measures of intensive treatment
- Adjunctive treatment of spastic muscular paresis
- (paraplegia/tetraplegia) caused by cerebral or spinal
- cord conditions such as stroke, multiple sclerosis, or spinal cord injury
- (long-term treatment is coupled with other rehabilitative measures)
- Palliative treatment of stiff person syndrome
- Pre- or postoperative sedation, anxiolysis or amnesia
- (e.g., before endoscopic or surgical procedures)
- Treatment of complications with a hallucinogen crisis and
- stimulant overdoses and psychosis, such as LSD, cocaine, or methamphetamine
Used in treatment of organophosphate poisoning and
reduces the risk of seizure induced brain and cardiac damage.
- Preventive treatment of oxygen toxicity during hyperbaric oxygen therapy
diazepam for anxiety
However, intravenous lorazepam has advantages over intravenous diazepam,
Diazepam is rarely used for the long-term treatment of epilepsy
because tolerance to its anticonvulsant effects usually develops